TABLE 6.
Cofactor interactions with the atoms of wild-type, C298S mutant hAR, and solvent
B, second molecule (molB) of the dimer; W, water molecule.
| NADP atoms | Dimeric hAR |
Distance | |
|---|---|---|---|
| Atom | Residue | ||
| Å | |||
| AOP1 | OG | Ser-263 | 2.67 |
| OG1 | Thr-265 | 2.64 | |
| AOP2 | NZ | Lys-262 | 2.63 |
| AOP3 | H | W132 | 2.79 |
| H | W49 | 2.54 | |
| AO2* | H | W132 | 2.9 |
| AO2* | NH1 | Arg-268 | 3.18 |
| AO3* | OE1 | BGln-26 | 3.16 |
| AO3* | OD2 | Asp-216 | 3.12 |
| AN7 | ND2 | Asn-272 | 3.07 |
| AN1 | H | W35 | 2.55 |
| AN6 | OD1 | Asn-272 | 2.93 |
| OE2 | Glu-272 | 2.81 | |
| AO1 | N | Ser-214 | 3.12 |
| N | Leu-212 | 2.86 | |
| AO2 | N | Lys-262 | 2.97 |
| NO1 | NZ | Lys-21 | 2.83 |
| NO2 | OG | Ser-210 | 2.76 |
| NO5* | N | Ser-210 | 3.07 |
| NO2* | OD2 | Asp-43 | 2.58 |
| NO3* | N | Trp-20 | 2.88 |
| NO3* | N | Thr-19 | 3.11 |
| NN7 | OE1 | Gln-183 | 3.09 |
| OG | Ser-159 | 2.80 | |
| NO7 | ND2 | Asn-160 | 2.79 |