FIGURE 2.

Effect of SF 6847 and/or inhibitors of the Ca²⁺ uniporter on mitochondrial Ca²⁺ uptake; modulation by cyclosporin A or genetic deletion of cyclophilin D. Traces of light scatter recorded spectrophotometrically at 520 nm during CaCl₂ additions at the concentrations are indicated in the panels, to mitochondrial suspensions. Conditions of the suspensions are given in the panels. All panels are aligned on the x axis. Results are representative of at least four independent experiments. E, maximum swelling rates pooled from all individual experiments (expressed as in Fig. 1) for each condition and after each Ca²⁺ pulse. Error bars represent S.E.; a is statistically significant from b, c, d, e, f, and g, p < 0.001; d is statistically significant from e, p < 0.05, one-way ANOVA on Ranks.