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Conformational change of SagUGL. A, superimposition of closed (red) and open (blue) forms of SagUGL WT (stereodiagram). The flexible loop moves with an oscillation width of 16.29 Å as indicated by the broken line. B, Δ6S (yellow) is accommodated at the active site of SagUGL D175N (cyan) in the closed form (stereodiagram). C, Gly-233 and Thr-235 binding to the substrate (stereodiagram).
