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. 2010 Dec 8;286(8):6233–6240. doi: 10.1074/jbc.M110.179184

FIGURE 4.

FIGURE 4.

Co-crystal structures of DENV-3 MTase in complex with compound 10*. A, superposition of the crystal structures of compound 10*-DENV-3 MTase (green) complex and the MTase-SAM complex (yellow). SAM is shown in stick representation. Compound 10* is colored in magenta. B, surface representation of the DENV-3 MTase, showing the binding of compound 10* (in stick presentation) in the identified cavity. C, representative omit (Fo − Fc) electron density map (green) at a level of 2.5 σ showing the bound compound 10* molecule. Amino acids Phe-133 and Arg-163 are labeled. D, compound-induced conformational change of amino acids. Compound 10* is shown in stick presentation (magenta). Residues Phe-133 and Arg-163 in the SAM-MTase complex are colored in yellow; the same residues in the compound 10*-MTase complex are shown in green; two arrows (red) indicate the compound-induced conformational change. E, schematic view of the interactions between compound 10* (brown) and the DENV-3 MTase (black).