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ITC analyses of STC and monastrol binding to Kinesin-5 motor domain in the presence of ATP. Shown is the heat evolved upon STC (A) or monastrol (B) binding to HsEg5, Klp61F-WT, Klp61F-L5, and Klp61F-L5-α3. Data are plotted versus molar ratio of effector/motor. Shown are representative traces from experiments performed in triplicate of three independent enzyme preparations.
