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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Nat Immunol. 2005 Nov 27;7(1):83–92. doi: 10.1038/ni1289

Figure 5.

Figure 5

Autoreactive CD4+CD25− TH cells and Treg cells from BDC2.5 mice home to the T cell zone and preferentially accumulate at the T cell–B cell boundary in the presence of autoantigen. CFSE-labeled BDC2.5 CD4+CD25− TH cells (a,c) and Treg cells (b,d) were transferred into NOD.Cd28−/− mice and the distribution of the transferred cells in inguinal lymph nodes (a,b) and pancreatic lymph nodes (c,d) was analyzed by immunohistochemistry 12 h later. B cell zones were labeled with anti-B220 staining and were developed with Fast Red (pink). Transferred cells were identified with anti-fluorescein developed with diaminobenzidine (dark brown). Results are representative of at least four mice in each group from independent experiments.