Table 3.

Studies of associations of genetics variants and antipsychotic-induced weight gain.

Gene/SNP	1st Author/year	Sample (n)	Study Design	Antipsychotic	p	Findings
5HT2C C759T (rs3813929)	Reynolds 2002183, 184	123 Chinese first- episode patients	10 weeks OL	Chlorpromazine Risperidone Clozapine fluphenazine	<.01	C allele was associated with higher weight gain
	Tsai 2002184	80 Chinese treatment- resistant patients	4 months OL	clozapine	n.s.	No association
	Basile 2002185	73 Caucasian and African American treatment-resistant patients	6 weeks OL	clozapine	n.s.	Non-significant trend towards higher weight gain associated with the T allele
	Reynolds 2003186	32 Chinese first- episode patients	6 weeks OL	clozapine	<.05	C allele and C/C genotype were associated with higher weight gain, especially in men
	Miller 2005187	41 American treatment- resistant patients	6 months OL	Clozapine	<.01	C allele was associated with higher weight gain
	Ellingrod 2005188	42 American acutely psychotic patients	6 weeks OL	Olanzapine	<.001	T allele was associated with less weight gain
	Templeman 2005189	73 Spanish Caucasian first-episode patients	10 weeks OL	Various APs	<.05	T allele was associated with less weight gain
	Theisen 2005190	97 Caucasian patients	Case-ontrol	clozapine	n.s.	No association
	Lane 2006191	123 Chinese acutely psychotic patients	6 weeks OL	risperidone	<.05	T allele was associated with less weight gain
	Ryu 2007192	84 Korean patients	4 week OL	Six antipsychotics	<.05	T allele was associated with less weight gain
	Park 2008193	79 Korean patients	3 months OL	olanzapine	n.s.	No association
	Ujike 200899	164 Japanese patients	8-24 weeks OL	olanzapine	n.s.	No association
	Kuzman 2008194	108 female Croatian Caucasian patients	4 months OL	Olanzapine risperidone	n.s.	No association
	Godlewska 2009195	107 Polish patients including 36 first- episode patients	6 weeks OL	olanzapine	<.01	T allele was associated with less weight gain
	Gunes 2009196	46 Swedish patients	Case-control	Olanzapine clozapine	<.05	C allele was associated with obesity in clozapine-treated patients
	Opgen-Rhein 2010197	128 German Caucasian patients	Case-control	Various AP	<.05	C allele was associated with more weight gain
	Thompson 201097	216 American aptients with mixed ethnicities	7 months OL	Iloperidone	n.s.	No association
GNB3 825-C/T	Tsai 2004198	87 Chinese patients	4 months OL	Clozapine	n.s.	No association
	Wang 2005199	134 Chinese patients	13 months OL	Clozapine	<.01	T/T genotype was associated with more weight gain
	Bishop 2006200	42 Caucasian patients	6 weeks OL	Olanzapine	n.s.	Non-significant trend toward TT genotype with more weight gain
	Ujike 200899	164 Japanese patients	8-24 weeks OL	olanzapine	<.05	T allele was associated with more weight gain
	Park 2009100	104 Korean patients	3 months OL	olanzapine	n.s.	No association