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. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Lupus. 2010 Apr;19(4):370–378. doi: 10.1177/0961203309360810

Figure 1.

Figure 1

Tissue factor (TF) induction of thrombosis. Model showing how induction of intravascular TF expression by anti-phospholipid antibody (aPL) may induce thrombosis in antiphospholipid syndrome (APS). aPL and bound antigen interact with cell surface receptors and induce TF expression on monocytes and endothelial cells with resultant increased TF expression and release of TF-positive microparticles (MP). This TF expression within the vasculature and blood may contribute to thrombosis in APS patients.