BPD-PDT followed by carboplatin synergistically reduces tumor viability. A, images of tumor viability (calcein and ethidium bromide fluorescence) following treatment. B, mean fraction viability in micronodules treated with either carboplatin alone or BPD-PDT alone was 0.92 (95% CI=0.88-0.97, n = 11) and 0.80 (95%CI=0.74-0.86, n = 15), respectively, relative to no treatment (grey dashed line). The combination treatment, BPD-PDT followed by carboplatin, reduced viability to 0.45 (95% CI=0.38-0.53, n = 11), indicating a significant synergism (p<0.0001, interaction term from ANCOVA). Scale bars = 250μm.