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. 2011 Mar 15;6(3):e16890. doi: 10.1371/journal.pone.0016890

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Su et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Phase diagram showing two regimes on the plane, assuming nm for DNA. Transition from de Gennes' to Odijk's regime can occur when decreases with fixed, or when increases with fixed. (B) DNA with local folded structures as an intermediate state between de Gennes's and Odijk's regimes. In experiments, we observe heterogeneity in the intensity profile of YOYO-1 dye along the backbone of a confined DNA, which suggests the existence of the local folded structures (see Supporting Information Fig. S2).

Inline graphic — (A) Phase diagram showing two regimes on the plane, assuming nm for DNA. Transition from de Gennes' to Odijk's regime can occur when decreases with fixed, or when increases with fixed. (B) DNA with local folded structures as an intermediate state between de Gennes's and Odijk's regimes. In experiments, we observe heterogeneity in the intensity profile of YOYO-1 dye along the backbone of a confined DNA, which suggests the existence of the local folded structures (see Supporting Information Fig. S2).