Table 1.

Characteristics of 450 lung cancer patients from the population-based case–control Environment and Genetics in Lung cancer Etiology study, including histology, smoking status, and human papillomavirus (HPV) status

Lung cancer histology	Smoking status, No. (%)				HPV DNA status by PCR* testing, No. (% HPV positive)
	Never	Former	Current	Unknown	Type-specific HPV16 and HPV18†	Broad-spectrum HPV typing‡
Adenocarcinoma (n = 246)	25 (83.3)	103 (52.0)	117 (53.2)	1 (50.0)	221 (0.0)	63 (0.0)
Squamous cell (n = 137)	2 (6.7)	68 (34.3)	66 (30.0)	1 (50.0)	123 (0.0)	27 (0.0)
Large cell (n = 30)	1 (3.3)	10 (5.1)	19 (8.6)	0 (0.0)	24 (0.0)	0 (0.0)
Small cell (n = 13)	0 (0.0)	5 (2.5)	8 (3.6)	0 (0.0)	11 (0.0)	0 (0.0)
Other (n = 24)§	2 (6.7)	12 (6.1)	10 (4.5)	0 (0.0)	20 (0.0)	2 (0.0)

^*PCR = polymerase chain reaction.

^†Results from 399 specimens with adequate DNA of 450 selected for testing.

^‡Results from 92 specimens with tumor present in the sample of 100 selected for testing.

^§Includes mixed type (adenosquamous, n = 10), synchronous (two different lung cancers, n = 6), non-small cells (n = 2), and other (including poorly differentiated, epithelial, neuroendocrine, mucoepidermoid, non-small cell, pleomorphic, sarcomatoid, n = 6).