Table 5.

Univariate and multivariate analyses for overall survival

	Univariate				Multivariate
			95% CI				95% CI
Variable	P	HR	Low	High	P	HR	Low	High
KPS *
≤ 60	< 0.001	1			< 0.001	1
70-80	0.03	0.69	0.50	0.96	0.04	0.70	0.49	0.99
≥ 90	< 0.001	0.35	0.23	0.55	< 0.001	0.40	0.25	0.65
Center *
1		1				1
2	< 0.001	0.50	0.35	0.71	0.007	0.59	0.41	0.87
Number of BM *
> 3	0.04	1			0.59	1
2 - 3	0.11	0.77	0.55	1.07	0.52	0.89	0.63	1.27
1	0.02	0.64	0.45	0.92	0.33	0.83	0.57	1.21
Primary Tumor *
Breast	0.05	1			0.08	1
Lung	0.02	1.59	1.08	2.36	0.04	1.57	1.02	2.41
Other	0.12	1.41	0.92	2.18	0.06	1.55	0.98	2.45
Control Primary *
NED or SD		1				1
PD	0.04	1.34	1.01	1.79	0.17	1.24	0.91	1.7
ExCr *
No		1				1
Yes	0.03	1.41	1.03	1.92	0.26	1.22	0.86	1.74
Age *
≥ 60	0.97	1			0.54	1
50-59	0.81	0.96	0.69	1.34	0.79	0.95	0.67	1.36
< 50	0.92	0.98	0.68	1.41	0.35	1.21	0.81	1.82
RPA **
I	0.002	1			0.02	1
II	0.44	1.19	0.77	1.84	0.51	1.16	0.74	1.82
III	0.003	2.08	1.29	3.35	0.01	1.91	0.16	3.14
GPA ***
3.5 - 4	0.001	1			0.03	1
3	0.75	1.23	0.33	4.57	0.79	1.19	0.32	4.43
1.5 - 2.5	0.32	1.80	0.57	5.69	0.42	1.62	0.51	5.16
0 - 1	0.07	2.95	0.93	9.34	0.14	2.40	0.74	7.74
BSBM ****
3	< 0.001	1			< 0.001	1
2	0.39	0.81	0.50	1.31	0.18	0.71	0.43	1.17
1	0.34	1.25	0.79	1.96	0.70	1.10	0.68	1.78
0	0.002	2.13	1.32	3.44	0.01	1.96	1.17	3.27

Abbreviations: KPS, Karnofsky performance status; BSBM, Basic Score for Brain Metastasis; RPA, Recursive Partitioning Analysis; GPA, Graded Prognostic Assessment; BM, Brain Metastasis; ExCr, Extra-cranial metastatic disease.

*: regression model with centers, primary site, its status (control), age, number of brain metastases, KPS and extra-cranial disease

**: RPA was adjusted on centers, primary site and number of brain metastases

***: GPA was adjusted on centers, primary site and its status (control)

****: BSBM was adjusted on centers, primary site, its status (control), age and number of brain metastases