Table 5.
Univariate | Multivariate | |||||||
---|---|---|---|---|---|---|---|---|
95% CI | 95% CI | |||||||
Variable | P | HR | Low | High | P | HR | Low | High |
KPS * | ||||||||
≤ 60 | < 0.001 | 1 | < 0.001 | 1 | ||||
70-80 | 0.03 | 0.69 | 0.50 | 0.96 | 0.04 | 0.70 | 0.49 | 0.99 |
≥ 90 | < 0.001 | 0.35 | 0.23 | 0.55 | < 0.001 | 0.40 | 0.25 | 0.65 |
Center * | ||||||||
1 | 1 | 1 | ||||||
2 | < 0.001 | 0.50 | 0.35 | 0.71 | 0.007 | 0.59 | 0.41 | 0.87 |
Number of BM * | ||||||||
> 3 | 0.04 | 1 | 0.59 | 1 | ||||
2 - 3 | 0.11 | 0.77 | 0.55 | 1.07 | 0.52 | 0.89 | 0.63 | 1.27 |
1 | 0.02 | 0.64 | 0.45 | 0.92 | 0.33 | 0.83 | 0.57 | 1.21 |
Primary Tumor * | ||||||||
Breast | 0.05 | 1 | 0.08 | 1 | ||||
Lung | 0.02 | 1.59 | 1.08 | 2.36 | 0.04 | 1.57 | 1.02 | 2.41 |
Other | 0.12 | 1.41 | 0.92 | 2.18 | 0.06 | 1.55 | 0.98 | 2.45 |
Control Primary * | ||||||||
NED or SD | 1 | 1 | ||||||
PD | 0.04 | 1.34 | 1.01 | 1.79 | 0.17 | 1.24 | 0.91 | 1.7 |
ExCr * | ||||||||
No | 1 | 1 | ||||||
Yes | 0.03 | 1.41 | 1.03 | 1.92 | 0.26 | 1.22 | 0.86 | 1.74 |
Age * | ||||||||
≥ 60 | 0.97 | 1 | 0.54 | 1 | ||||
50-59 | 0.81 | 0.96 | 0.69 | 1.34 | 0.79 | 0.95 | 0.67 | 1.36 |
< 50 | 0.92 | 0.98 | 0.68 | 1.41 | 0.35 | 1.21 | 0.81 | 1.82 |
RPA ** | ||||||||
I | 0.002 | 1 | 0.02 | 1 | ||||
II | 0.44 | 1.19 | 0.77 | 1.84 | 0.51 | 1.16 | 0.74 | 1.82 |
III | 0.003 | 2.08 | 1.29 | 3.35 | 0.01 | 1.91 | 0.16 | 3.14 |
GPA *** | ||||||||
3.5 - 4 | 0.001 | 1 | 0.03 | 1 | ||||
3 | 0.75 | 1.23 | 0.33 | 4.57 | 0.79 | 1.19 | 0.32 | 4.43 |
1.5 - 2.5 | 0.32 | 1.80 | 0.57 | 5.69 | 0.42 | 1.62 | 0.51 | 5.16 |
0 - 1 | 0.07 | 2.95 | 0.93 | 9.34 | 0.14 | 2.40 | 0.74 | 7.74 |
BSBM **** | ||||||||
3 | < 0.001 | 1 | < 0.001 | 1 | ||||
2 | 0.39 | 0.81 | 0.50 | 1.31 | 0.18 | 0.71 | 0.43 | 1.17 |
1 | 0.34 | 1.25 | 0.79 | 1.96 | 0.70 | 1.10 | 0.68 | 1.78 |
0 | 0.002 | 2.13 | 1.32 | 3.44 | 0.01 | 1.96 | 1.17 | 3.27 |
Abbreviations: KPS, Karnofsky performance status; BSBM, Basic Score for Brain Metastasis; RPA, Recursive Partitioning Analysis; GPA, Graded Prognostic Assessment; BM, Brain Metastasis; ExCr, Extra-cranial metastatic disease.
*: regression model with centers, primary site, its status (control), age, number of brain metastases, KPS and extra-cranial disease
**: RPA was adjusted on centers, primary site and number of brain metastases
***: GPA was adjusted on centers, primary site and its status (control)
****: BSBM was adjusted on centers, primary site, its status (control), age and number of brain metastases