Table 2.
MOS-SF-36 Quality of Life Domains for Cohorts 1 and 2 (mean [95% confidence intervals]; probability).
| Cohort 1 | Cohort 2 | ||||||
|---|---|---|---|---|---|---|---|
| Domain | HC n = 295 |
CFS * n = 145 |
HC n = 19 |
CFS ** n = 49 |
CFS+MO** n = 28 |
CFS+MA** n = 12 |
CFS+T ** n = 9 |
| Physical Functioning | 71.6 [67.8-75.4] |
47.6 [43.4-52.1] p < 10-10 |
91.1 [82.4-99.7] |
41.4 [34.6-48.2] p < 10-10 |
43.7 [35.5-51.9] p = 10-9 |
28.8 [15.6-41.9] p = 10-8 |
51.7 [34.5-68.8] p = 0.0001 |
| Social Functioning | 67.4 [63.2-71.6] |
46.4 [41.8-51.0] p = 10-9 |
87.5 [76.5-98.5] |
26.9 [21.0-32.8] p < 10-10 |
25.5 [17.9-33.0] p < 10-10 |
23.9 [9.3-38.4] p = 10-7 |
35.9 [26.2-45.7] P = 0.000005 |
| Role-Physical | 60.5 [63.2-71.6] |
18.5 [13.3-23.7] p < 10-10 |
76.3 [57.8-94.9] |
5.6 [0.8-10.4] p < 10-10 |
8.0 [0.5-15.6] p = 10-9 |
4.2 [-4.0-12.3] p = 10-6 |
0 P = 0.000009 |
| Role-Emotional | 71.6 [62.8-80.3] |
53.3 [46.2-60.5] p = 0.008 |
86.0 [72.5-99.5] |
57.6 [44.8-70.5] |
59.3 [42.0-76.5] p = 0.03 |
55.6 [28.5-82.7] p = 0.04 |
55.6 [24.8-86.4] p = 0.048 |
| Mental Health | 66.8 [63.0-70.5] |
58.4 [54.9-61.9] p = 0.006 |
79.2 [74.0-84.3] |
62.6 [57.0-68.3] |
64.9 [57.9-71.8] p = 0.005 |
59.7 [45.1-74.2] p = 0.007 |
59.6 [48.1-71.0] p = 0.001 |
| Vitality | 50.1 [47.1-53.1] |
25.4 [22.3-28.5] p < 10-10 |
66.1 [56.5-75.8] |
13.9 [10.5-17.2] p < 10-10 |
14.8 [10.3-19.3] p < 10-10 |
6.7 [2.1-11.2] p = 10-10 |
20.6 [12.6-28.5] p = 10-6 |
| Bodily Pain | 60.5 [56.5-64.6] |
35.1 [31.4-38.8] p < 10-10 |
83.8 [72.4-95.2] |
34.1 [28.1-40.2] p < 10-10 |
32.8 [25.3-40.3] p = 10-9 |
30.6 [16.2-44.9] p = 10-6 |
42.8 [29.5-56.0] p = 0.0003 |
| General Health | 64.5 [56.5-64.6] |
38.3 [34.3-42.3] p < 10-10 |
76.8 [69.5-84.2] |
33.0 [27.8-38.2] p < 10-10 |
36.2 [28.3-44.1] p = 10-8 |
28.8 [19.9-37.6] p = 10-8 |
29.1 [20.9-37.4] p = 10-8 |
2-tailed unpaired Student's t-tests with Bonferroni corrections following ANOVA (p < 0.05): * vs. HC of Cohort 1 and ** vs. HC of Cohort 2.