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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Nov 11;30(12):2392–2399. doi: 10.1161/ATVBAHA.110.211615

Figure 5. Anti-platelet treatments suppress H/R-induced formation of platelet-neutrophil aggregates, neutrophil activation and lung vascular permeability in SCD mice.

Figure 5

(A) WT and SCD mice were subjected to 3 h hypoxia (8% O2 -92% N2) followed by 3 h reoxygenation (H/R). Prior oral treatment with clopidogrel (3 days), injection of 100 μg of anti-P-selectin antibody or platelet depletion with anti GPIbα antibody prevented formation of platelet-neutrophil aggregates in SCD mice. (B), Platelet depletion with anti-GPIbα-antibody (24 hrs) reduced pulmonary vascular leak measured with Evans blue dye (EBD). Data are expressed as means ± SD (n=3). **p<0.005, ***p<0.001.