Table 5. Estimated frequency of common haplotypes and their associations with significant coronary artery disease with respect to the presence of T2DM.
Non-diabetic patients | Diabetic patients | |||||||||
Haplotype | CAD (−) % | CAD (+) % | OR [95%CI] | P value | CAD (−) % | CAD (+) % | OR [95%CI] | P value | ||
rs7903146 C>T | rs12255372 G>T | rs11196205 G>C | ||||||||
C | G | G | 53.1 | 54.6 | 1.06 [0.91–1.24] | 0.468 | 55.6 | 45.8 | 0.67 [0.50–0.90] | 0.009 |
C | G | C | 15.6 | 13.7 | 0.86 [0.69–1.08] | 0.193 | 11.8 | 12.0 | 1.03 [0.65–1.62] | 0.908 |
C | T | C | 1.9 | 1.0 | 0.53 [0.26–1.01] | 0.050 | 2.8 | 2.4 | 0.86 [0.34–2.21] | 0.755 |
T | G | C | 3.5 | 3.5 | 1.01 [0.65–1.54] | 0.983 | 4.6 | 3.0 | 0.66 [0.31–1.42] | 0.286 |
T | T | C | 25.2 | 26.7 | 1.08 [0.90–1.29] | 0.410 | 24.3 | 35.1 | 1.67 [1.19–2.22] | 0.003 |
ORs (odds ratios), 95%CIs (confidence intervals), and p values were calculated by chi-squared tests by comparing each haplotype to all remaining haplotypes. CAD indicates coronary artery disease.