Table 4.
MEDI-528 Multiple-Dose Pharmacokinetic Parameters in Study 1
| Cohort | Cmax (μg/mL) |
Tmax (day) |
T1/2 (day) |
Accumulation index* |
|---|---|---|---|---|
| 0.3 mg/kg (n = 9) |
13.7 ± 2.7† | 3.5 ± 2.1† | 37.1 ± 7.5† | 5.2 ± 2.0‡ |
| 1 mg/kg (n = 9) |
52.1 ± 33.0 | 3.7 ± 2.3 | 35.0 ± 11.5 | 9.9 ± 4.5 |
| 3 mg/kg (n = 9) |
105.5 ± 31.0 | 3.9 ± 2.6 | 37.7 ± 7.5 | 6.7 ± 1.8 |
Values are mean ± SD. Cmax = maximum concentration; Tmax = time to maximum concentration; T1/2 = half-life.
*Accumulation index was based on trough concentration after first and last dose.
†n = 8.
‡n = 7.