Table 4.

m.3243A > G Load in Extra-Embryonic and Embryo-Fetal Tissues

	Patient	Fetus	CVS	AF1	AF2	Muscle	Liver	Heart	Skin	Kidney	Lung	Gut	Brain	Optic nerve	Thymus	Umbilical cord	Placenta	Cord blood
A	2	2a	77 ± 3			75 ± 1.5		74 ± 3.2			74 ± 0						73, 75a
		2b	59 ± 6			42 ± 1		41 ± 2	42 ± 2	43 ± 2	43 ± 0.3						57 ± 2b
		2c		4 ± 0													15 ± 5c	5 ± 1
	3	3	17 ± 3	16 ± 0.5													22 ± 6d	16 ± 0
	4	4		0														0
	5	5a	20 ± 0.5	15 ± 3	15 ± 2
		5b		70 ± 1			72 ± 2		73 ± 0	68 ± 2					72 ± 1
		5c	4 ± 0.6
	6	6	32 ± 1	28 ± 1
	7	7a				79 ± 0	78 ± 0.6	77 ± 0.9	78 ± 0.3	79 ± 0	79 ± 0.3					78 ± 1.7	78 ± 1.7
		7b	79 ± 2
	8	8	49 ± 0.7
B	9	9				55 ± 1	52 ± 4	54 ± 3	51 ± 3	56 ± 5		53 ± 4	52 ± 3	51 ± 3			55 ± 3
	10	10				50	50						50
	11	11			67
	12	12a	35	33	29
		12b	31	23	26
	13	13a	60	63
		13b	0	0
		13c	0	0

A, Fetuses analyzed in this study. Chorionic villi (CVS) were sampled at 10 GW, and amniotic fluids (AF) at 14 (AF1) and 30 (AF2) GW, respectively. The other tissues were sampled at 12 GW (fetuses 2a and 2b), or at 19, 20, 24, and 25 GW for fetuses 5b, 7, 9, and 10, respectively, and at term for fetuses 2c and 3. Cord blood was sampled at birth for fetuses 2c (38 GW), 3 (37 GW), and 4 (39 GW). All assays were carried out in triplicate. Values are expressed as mean ± SD. Placenta values measured on ^a2, ^b6, ^c10, and ^d18 separate biopsies, respectively (SD: intersample variation). B, Fetuses reported elsewhere: [9] Matthews et al., 1994, [10] Cardaioli et al., ²⁰⁰⁰, [11] Chou et al., ²⁰⁰⁴, [12,13] our group [Bouchet et al., ²⁰⁰⁶]. In boldface: patients born after PGD or PND.