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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Biol Psychiatry. 2010 Dec 17;69(7):650–660. doi: 10.1016/j.biopsych.2010.09.055

Table 2.

Frequencies of Haplotypes Within 15q25. High-quantity smokers are compared to Low-quantity/non-smokers in Adolescence and Mid-adulthood (χ2-test).*

Smoking at 14 years Smoking at 31 years
Haplotype df Hap frequency Regular-smokers (N=279) Hap frequency Occasional+non-smokers (N=4278) χ2 p Hap frequency Heavy-smokers (N=932) Hap frequency Light+non-smokers (N=3,536) χ2 p
Block 1a Global test 8 NA NA 14.44 0.07 NA NA 21.39 0.006
GAAAGAAGGA 1 0.28 0.26 1.44 0.23 0.29 0.25 11.73 0.0006
AAAGAGGGGA 1 0.05 0.03 3.24 0.07 0.04 0.04 0.90 0.34
AAAGAGGGAG 1 0.25 0.31 8.18 0.004 0.29 0.31 3.49 0.06
AAGAGAGAGA 1 0.25 0.26 0.28 0.59 0.24 0.27 5.28 0.02
AAAAGAGAGA 1 0.02 0.02 1.16 0.28 0.01 0.02 0.88 0.35
AAAGAGGGGG 1 0.01 0.01 0.00 0.96 0.01 0.01 1.96 0.16
GGAAGAAGGA 1 0.08 0.06 2.95 0.08 0.07 0.06 1.80 0.18
AAAGAGGGAA 1 0.03 0.03 0.31 0.58 0.03 0.03 0.00 0.97
AAGAGAGGGA 1 0.02 0.02 0.16 0.69 0.02 0.02 1.03 0.31
Block 2b Global test 6 NA NA 12.20 0.06 NA NA 23.85 0.0006
GAGCGGAA 1 0.38 0.33 4.55 0.03 0.37 0.33 10.90 0.001
GAAAGAGG 1 0.26 0.28 0.98 0.32 0.25 0.28 4.56 0.03
GGAAAGGG 1 0.12 0.14 1.79 0.18 0.14 0.15 0.10 0.76
AAAAAGGG 1 0.16 0.14 1.64 0.20 0.15 0.14 1.62 0.20
GAAAAGGG 1 0.01 0.14 0.95 0.03 0.01 0.03 9.27 0.002
GAGCGGGG 1 0.02 0.02 0.00 0.97 0.01 0.02 0.55 0.16
AAAAGGGG 1 0.06 0.07 0.73 0.39 0.07 0.07 2.39 0.12
a

SNPs in Block 1: rs8034191, rs3885951, rs2036534, rs6495306, rs680244, rs621849, rs1051730, rs6495309, rs1948, rs950776

b

SNPs in Block 2: rs12594247, rs12900519, rs1996371, rs6495314, rs8032156, rs8038920, rs4887077, rs11638372

P<0.05 are in bold