Table 5.

Total, Direct, and Indirect Effects of TTC12-rs10502172 and CHRNA3-rs1051730 on Smoking at 14 and 31 Years (see also Table S10 in Supplement 1)

	β (SE)a		Standardized βa	P Value
TTC12-rs10502172[G]to smoking at 14
Total	0.152	(0.034)	0.104	<0.001
CHRNA3-rs1051730[A]to smoking at 14
Total	0.063	(0.034)	0.041	0.07
TTC12-rs10502172[G]C to smoking at 31
Total	0.091	(0.037)	0.052	0.01
Total indirect	0.073	(0.017)	0.042	<0.001
1) TTC12→NS→Smoking31	0.007	(0.004)	0.004	0.06
2) TTC12→Smoking14→Smoking31	0.066	(0.016)	0.038	<0.001
Direct	0.018	(0.038)	0.010	0.63
CHRNA3-rs1051730[A] to smoking at 31
Total	0.158	(0.038)	0.086	<0.001
Total indirect	0.026	(0.016)	0.014	0.10
1) CHRNA3→NS→Smoking31	−0.001	(0.003)	0.000	0.78
2) CHRNA3→Smoking14→Smoking31	0.027	(0.015)	0.015	0.07
Direct	0.131	(0.037)	0.071	<0.001

Abbreviations: NS, Novelty Seeking.

^aThe Estimates are probit regression estimates from the SEM model fitted to the data.