TABLE 4.

Cumulative incidence of diseases associated with >1% cholestasis in infancy

Diagnosis	N	per 10,000	1 in “x”	Cholestatic†
Bliary tract disorders	81	3.0	1 in 3348	63.0%
Biliary atresia	27	1.0	1 in 10040	100.0%
Liver diseases	142	5.2	1 in 1910	35.2%
Viral hepatitides	26	1.0	1 in 10428	30.8%
Gastrointestinal disorders	706	26.0	1 in 384	5.1%
Intestinal atresia	143	5.3	1 in 1896	4.9%
Hirschsprung’s disease	76	2.8	1 in 3568	1.3%
Metabolic disorders	334	12.3	1 in 812	3.6%
Down’s Syndrome	259	9.6	1 in 1047	3.5%
Severe bacterial infections	2152	79.4	1 in 126	1.3%

^†Cholestatic refers to subjects with a maximum CB ≥2 mg/dL or DB ≥5 mg/dL in their 1st year after birth