Figure 7.

Baicalein improves the learning and memory performances in contextual fear conditioning tests. (A) Experimental design of fear conditioning paradigm. (B) Total percentage of freezing during the 3 min contextual fear conditioning test when tested 24 h after conditioning. Baicalein improved contextual fear conditioning at 20 mg·kg⁻¹ and 50 mg·kg⁻¹. n= 8, *P < 0.05 versus control. (C) Total percentage of freezing during the presentation of the tones in the cued fear conditioning test when tested 1 h after contextual fear conditioning test. Groups did not differ in freezing to the tone during the cued fear conditioning test compared with controls. (D) Distance travelled during the initial 3 min exposure to the training box in an open field test. (E) Pain thresholds. Thresholds of current intensities for flinching and running/jumping are shown.