Table 2.

Clinical parameters of the study groups at the time of death (58 weeks of age)

	LETO	OLETF-CON	OLETF-SIL
Total kidney weight (g)	2.61 ± 0.04	3.61 ± 0.09***	3.71 ± 0.12
Kidney weight/body weight	4.94 ± 0.07	5.58 ± 0.14**	5.60 ± 0.15
Blood urea nitrogen (mg·L−1)	302.30 ± 4.20	217.90 ± 7.50***	283.10 ± 9.20##
Serum creatinine (mg·L−1)	4.10 ± 0.20	2.70 ± 0.10***	3.10 ± 0.20#
Creatinine clearance (mL·min−1)	2.08 ± 0.17	2.79 ± 0.20*	2.54 ± 0.14
Total cholesterol (mg·L−1)	1296.70 ± 28.80	1562.50 ± 93.60*	1666.30 ± 104.10
Triglycerides (mg·L−1)	60.83 ± 10.68	293.38 ± 44.00***	270.25 ± 66.60
Urine cGMP
nmol·24 h−1	30.45 ± 1.99	37.12 ± 1.89**	50.29 ± 5.56#
nmol·mg−1 creatinine	1.80 ± 1.05	2.45 ± 0.65***	3.15 ± 0.26#

Data are mean ± SEM.

^*P < 0.05,

^**P < 0.01,

^***P < 0.001 vs. LETO.

^#P < 0.05,

^##P < 0.001 vs. OLETF-CON.

LETO, Long-Evans Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima Fatty.