Table 4.

Associations between ARG2 haplotypes and SNP and FeNO

Haplotypes*	Percent Difference in FeNO (95% CI)†	P-value‡
h1000100000	Reference
h0000000010	−6.6 (−11.0, −1.9)	0.006
h1000000010	−4.0 (−9.4, 1.8)	0.17
h0000000100	0.7 (−4.4, 6.1)	0.79
h1111011101	0.0 (−6.5, 6.9)	0.99
h0111010100	−3.9 (−10.9, 3.7)	0.30
h0011010101	1.4 (−4.1, 7.1)	0.63
h0000011101	−3.6 (−11.1, 4.6)	0.38
Other haplotypes	−2.0 (−6.9, 3.1)	0.44
rs3742879	−4.8 (−7.7, −1.7)	0.02§

^*SNP order in ARG2 haplotypes is rs12885261-rs7144243-rs3759757-rs4902501-rs7156352-rs4902503-rs7140310-rs742869-rs3742879-rs10483801. Within each haplotype, ‘0’ and ‘1’ represents the common and the variant alleles at the ordered SNP position, respectively. Within each haplotype, “0” and “1” represent the common and the variant alleles at the ordered SNP position, respectively.

^†Percent difference in FeNO and 95 % confidence intervals (95% CIs) associated with each haplotype compared to the most common haplotype (reference) and per variant G allele for rs3742879 were obtained. All models include adjustment for covariates listed in the ‘Methods’ section.

^‡P-values for the association between the haplotypes or SNP and FeNO.

^§P-value for rs3742879 is adjusted for multiple testing using Bonferroni correction.