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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Allergy. 2010 Oct 6;66(3):412–419. doi: 10.1111/j.1398-9995.2010.02492.x

Table 5.

Associations between NOS2A promoter haplotype and FeNO within each ARG2 rs3742879 genotype

ARG2 rs3742879 A>G genotypes NOS2A Block 3 h1000010
AA
 Percent difference in FeNO* 5.6 (1.3, 10.1)
 N 1487
 P-value† 0.01
AG
 Percent difference in FeNO* 0.9 (−3.8, 5.8)
 N 1044
 P-value† 0.71
GG
 Percent difference in FeNO* −8.9 (−17.6, 0.7)
 N 215
 P-value† 0.07
P- interaction‡ 0.009
*

Percent difference in FeNO and 95 % confidence intervals (95% CIs) associated with per copy of haplotype were obtained from models stratified by ARG2 rs3742879 genotypes. All models include adjustment for covariates listed in the ‘Methods’ section.

†

P-values for the association between the haplotypes and FeNO within each ARG2 rs3742879 genotype.

‡

P-values for interaction for ARG2 rs3742879 by NOS2A haplotypes using additive genetic model were obtained from likelihood ratio tests from non-stratified models with appropriate interaction terms and were based on 1 degree of freedom.