TABLE 2.
Laboratory values in patients with nonalcoholic fatty liver with and without stainable iron.
| Characteristic | Iron stain negative (N=556) | Iron stain positive (N=293) | P-value† |
|---|---|---|---|
| Laboratory values’‡ | |||
| ALT (U/L) | 63 (42–91) | 75 (50–111) | 0.004 |
| AST (U/L) | 45 (32–68) | 48 (33–67) | 0.39 |
| AST/ALT | 0.74 (0.59–0.92) | 0.66 (0.51–0.84) | 0.0002 |
| Total bilirubin (mg/dL) | 0.6 (0.5–0.8) | 0.8 (0.6–1.0) | <0.0001 |
| Prothrombin time (sec) | 11.8 (10.3–12.7) | 12.0 (10.6–13.1) | 0.09 |
| Total cholesterol (mg/dL) | 200 (176–224) | 190 (166–222) | 0.02 |
| Triglycerides (mg/dL) | 159 (114–232) | 152 (105–214) | 0.26 |
| LDL (mg/dL) | 121(93–148) | 116 (90–141) | 0.10 |
| HDL (mg/dL) | 43 (36–51) | 39 (34–49) | 0.004 |
| Glucose (mg/dL) | 97 (86–110) | 95 (85–108) | 0.54 |
| Fasting insulin(μU/mL) | 18.8 (13–29) | 17.7 (11.8–26.0) | 0.10 |
| HOMA–IR | 4.6 (3.0–7.5) | 4.4 (2.5–6.5) | 0.10 |
| Platelets (K/cmm) | 255 (220–293) | 216 (179–261) | <0.0001 |
| Hemoglobin (g/dL) | 14.1 (13.4–15.0) | 15.1 (14.3–15.9) | <0.0001 |
| Serum iron studies | |||
| Iron (μg/dL) | 81 (61–103) | 103 (80–123) | <0.0001 |
| TIBC (μg/dL) | 380(337–424) | 336 (301–384) | <0.0001 |
| Ferritin (ng/mL) | 106 (62–192) | 328 (221–526) | <0.0001 |
| TS (iron/TIBC) | 0.21 (0.16–0.27) | 0.29 (0.23–0.39) | <0.0001 |
Values aremedian (IQR)
†
P-values from Wilcoxon rank-sum test.
‡
Only laboratory values collected within 6 months of liver biopsy included, N=573.