Table 4.
Histologic Features | No iron stain (N=556) | HC iron only (N=63) | RES iron only (N=91) | Mixed HC/RES iron (N=139) | P value† |
---|---|---|---|---|---|
Steatosis grade | p=0.170 | ||||
5–33% | 220 (40%) | 27 (43%) | 35 (38%) | 71 (51%) | |
34–66% | 190 (34%) | 24 (38%) | 29 (32%) | 35 (25%) | |
>66% | 146 (26%) | 12 (19%) | 27 (30%) | 33 (24%) | |
Fibrosis stage | p=0.092 | ||||
None | 144 (26%) | 25 (40%) | 11 (12%) | 33 (24%) | |
Mild to moderate, zone 3, perisinusoidal or portal/periportal only | 155 (28%) | 18 (28%) | 27 (30%) | 41 (29%) | |
Zone 3 and periportal, any combination | 104 (19%) | 8 (13%) | 19 (21%) | 25 (18%) | |
Bridging | 108 (19%) | 10 (16%) | 24 (26%) | 27 (19%) | |
Cirrhosis | 45 (8%) | 2 (3%) | 10 (11%) | 13 (9%) | |
Lobular inflammation | |||||
0 | 0 (0%) | 0 (0%) | 0 (0%) | 2 (1%) | p=0.110 |
<2 under 20x | 275 (50%) | 36 (57%) | 37 (41%) | 73 (53%) | |
2–4 under 20x | 213 (38%) | 22 (35%) | 44 (48%) | 53 (38%) | |
>4 under 20x | 68 (12%) | 5 (8%) | 10 (11%) | 11 (8%) | |
Portal, chronic inflammation | |||||
None | 81 (15%) | 9 (14%) | 10 (11%) | 23 (17%) | p=0.017 |
Mild | 355 (64%) | 48 (76%) | 52 (57%) | 77 (55%) | |
More than mild | 120 (21%) | 6 (10%) | 29 (32%) | 39 (28%) | |
Hepatocellular ballooning | |||||
None | 166 (30%) | 30 (48%) | 25 (28%) | 50 (36%) | p=0.005 |
Mild | 136 (24%) | 18 (28%) | 22 (24%) | 42 (30%) | |
More than mild | 254 (46%) | 15 (24%) | 44 (48%) | 47 (34%) | |
NASH diagnosis | |||||
No NASH | 106 (19%) | 19 (30%) | 12 (13%) | 33 (24%) | p=0.049 |
Suspicious/borderline | 105 (19%) | 16 (25%) | 17 (19%) | 30 (21%) | |
Definite | 345 (62%) | 28 (44%) | 62 (68%) | 76 (55%) | |
Hepatocellular iron grade | |||||
Absent or barely discernable, 40x | 556 (100%) | 0 (0%) | 91 (100%) | 0 (0%) | p=0.001 |
Barely discernable granules, 20x | 0 (0%) | 52 (83%) | 0 (0%) | 80 (58%) | |
Discrete granules resolved, 10x | 0 (0%) | 11 (17%) | 0 (0%) | 49 (35%) | |
Discrete granules resolved, 4x | 0 (0%) | 0 (0%) | 0 (0%) | 10 (7%) | |
RES iron grade | |||||
None | 556 (100%) | 63 (100%) | 0 (0%) | 0 (0%) | P<0.001 |
Mild | 0 (0%) | 0 (0%) | 74 (81%) | 79 (57%) | |
More than mild | 0 (0%) | 0 (0%) | 17 (19%) | 60 (43%) |
Values are N (%)
P-values from either Fisher’s exact or chi-square tests as appropriate.