Table 1. European ancestry individuals enrolled in participating studies.
| GOCHA | GERFHS | JUHSS | MUG-ICH | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | |
| No. of Subjects |
398 | 312 | 555 | 203 | 337 | 1304 | 102 | 130 | 429 | 77 | 114 | 1023 |
| Age - Mean (SD) |
73.4 (10.3) |
70.2 (12.4) |
73.1 (8.03) |
64.3 (17.1) |
64.0 (15.5) |
60.8 (15.2) |
63.2 (13.3) |
67.5 (14.1) |
63.6 (13.0) |
70.2 (13.2) |
68.1 (13.6) |
65.2 (8.0) |
| Gender (% Female) |
46 | 43 | 45 | 45 | 51 | 47 | 48 | 48 | 53 | 45 | 48 | 43 |
| Hypertension (%) |
77 | 86 | 72 | 52 | 74 | 48 | 73 | 81 | 48 | 60 | 67 | 50 |
| APOE ε2 (MAF) |
0.11 | 0.07 | 0.07 | 0.15 | 0.10 | 0.10 | 0.13 | 0.09 | 0.08 | 0.09 | 0.07 | 0.07 |
| APOE ε4 (MAF) |
0.21 | 0.15 | 0.12 | 0.21 | 0.16 | 0.15 | 0.13 | 0.11 | 0.08 | 0.13 | 0.11 | 0.10 |
| HM-ICH | LUHSS | VHH-ICH | US-AA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | Lobar ICH |
Deep ICH |
Controls | |
| No. of Subjects |
66 | 103 | 185 | 42 | 89 | 161 | 43 | - | 87 | 63 | 110 | 297 |
| Age - Mean (SD) |
76.8 (10.0) |
70.7 (12.6) |
69.3 (7.1) |
74.5 (9.4) |
74.9 (10.2) |
74.3 (9.6) |
72.6 (6.5) |
- | 70.8 (6.7) |
63.4 (17.5) |
59.8 (13.6) |
55.5 (14.6) |
| Gender (% Female) |
46 | 48 | 51 | 47 | 48 | 43 | 42 | - | 40 | 50 | 46 | 45 |
| Hypertension (%) |
48 | 59 | 42 | 51 | 62 | 42 | 55 | - | 42 | 55 | 58 | 52 |
| APOE ε2 (MAF) |
0.11 | 0.09 | 0.08 | 0.11 | 0.09 | 0.09 | 0.10 | - | 0.08 | 0.15 | 0.12 | 0.10 |
| APOE ε4 (MAF) |
0.13 | 0.11 | 0.09 | 0.20 | 0.18 | 0.16 | 0.12 | - | 0.09 | 0.24 | 0.20 | 0.19 |
GERFHS = Genetic and Environmental Risk Factors for Hemorrhagic Stroke Study at the University of Cincinnati (Cincinnati, OH, USA), GOCHA = Multi-center North-American (USA) Genetics of Cerebral Hemorrhage on Anticoagulation Study, HM-ICH = Hospital del Mar (Barcelona, Spain) ICH Study, JUHSS = Jagiellonian University (Krakow, Poland) Hemorrhagic Stroke Study, LUHSS = Lund University (Lund, Sweden) Hemorrhagic Stroke Study, MUG-ICH = Medical University of Graz (Graz, Austria) ICH Study, US-AA: African-American subjects recruited in the USA (Boston and Cincinnati) as part of the GOCHA and GERFHS studies, VHH-ICH = Val d’Hebron Hospital (Barcelona, Spain) ICH Study. ICH = Intracerebral Hemorrhage, MAF = Minor Allele Frequency, SD = Standard Deviation