Table.
Performance of human papillomavirus testing in detecting subjects with high grade disease according to age, smear history, and cut off value of test
| Cut off value of test (pg/ml) | Test performance (%) (95% CI)
|
||||
|---|---|---|---|---|---|
| Sensitivity | Specificity | Predictive values*
|
|||
| Positive | Negative | ||||
| Age† | |||||
| <30 yr (n=166) | 1 | 94 (86 to 98) | 33 (24 to 43) | 51 (43 to 60) | 89 (74 to 96) |
| ⩾30 yr (n=167) | 1 | 91 (79 to 97) | 72 (64 to 79) | 55 (43 to 65) | 96 (89 to 98) |
| Smear history | |||||
| Borderline (n=75) | 1 | 86 (65 to 95) | 76 (63 to 85) | 58 (41 to 74) | 93 (82 to 98) |
| Mild dyskaryosis (n=117) | 1 | 94 (84 to 98) | 39 (29 to 52) | 55 (44 to 65) | 90 (74 to 96) |
| Both types (n=141) | 1 | 95 (85 to 99) | 54 (44 to 63) | 48 (38 to 59) | 96 (88 to 99) |
| All (n=333) | 1 | 93 (87 to 97) | 55 (48 to 61) | 52 (46 to 59) | 94 (88 to 97) |
| 2 | 91 (85 to 95) | 57 (51 to 64) | 53 (46 to 60) | 93 (87 to 96) | |
| 4 | 85 (78 to 91) | 62 (55 to 68) | 54 (47 to 62) | 89 (83 to 93) | |
*
Adjusted for prevalence of high grade disease.
†
That there were almost exactly the same number of subjects in each of the two age groups was coincidental.