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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Epilepsia. 2011 Jan 4;52(3):523–530. doi: 10.1111/j.1528-1167.2010.02919.x

Figure 3. Effect of Muscimol injection into the MD on Seizures Generated in the Subiculum.

Figure 3

Injection of muscimol into the MD caused a reduction or ablation of seizures that were generated in the subiculum and recorded in the PFC. (A) Map of injection sites, including successful (seizure durations affected) and unsuccessful (no effect on seizures) injections. Note that successful injections were clustered in and around the MD. (B) Sample seizure showing reduction in seizure duration with muscimol application, and subsequent recovery. (C) Average seizure changes before, during and after a successful injection of muscimol in MD (n=7), showing significant reduction in duration. P<0.05 by paired t-test. (D) Sample unsuccessful injection, in which seizure duration did not change. (E) Average seizure durations before and after unsuccessful injections, showing no significant change (n=5).