Table 3.

Safety of tPA Use.

	Unadjusted				Adjusted*
	Community vs. NINDS treatment		Community vs. NINDS placebo		Community vs. NINDS treatment		Community vs. NINDS placebo
One-year mortality (Cox model) RR (95% CI)	1.20	(0.87–1.64)	1.04	(0.76–1.41)	1.25	(0.90–1.75)	1.09	(0.79–1.52)
Intracerebral Hemorrhage (sICH within 36 h) OR (95% CI)	1.03	(0.53–1.98)			1.02	(0.51–2.07)
Functional recovery (mRS ≤ 2) OR (95% CI)	0.83	(0.53–1.29)	1.46	(0.99–2.15)	0.67	(0.39–1.16)	1.07	(0.67–1.70)

^*Outcomes adjusted for baseline variables: age, diabetes, stroke severity, and prior stroke. sICH = significant/symptomatic intracerebral hemorrhage, RR = relative risk; OR = odds ratio; mRS = modified Rankin Scale; NINDS = National Institute of Neurological Disorders and Stroke