Table 1.
Demographics, baseline characteristics, and predisposing conditions of the study population.
| Case # |
Age (y) |
Gender | DVT Site(s) |
PE at presen- tation |
Lag time from sx onset to dx (d) |
Lag time from dx to thrombo- lytic rx (d) |
Clinical triggers |
Acute thrombo- philia findings |
Vascular anomaly |
Other diagnoses |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 16 | F | L iliac, fem, pop |
No | 1 | 45 | Immobility | FVIII, LA, FVL het, PS (mild, acquired) |
May- Thurner |
Juvenile rheumatoid Arthritis |
| 2 | 17 | F | L iliac, fem, pop |
No | 3 | 0 | OCP Trauma |
FVIII, LA | May- Thurner |
APS |
| 3 | 16 | M | R SC, ax, basilic |
No | 10 | 0 | None | LA, beta-2- gp-I |
Paget- Schroetter |
APS |
| 4 | 17 | F | L iliac, Fem |
No | 7 | 26 | OCP Trauma |
n/a | May- Thurner |
APS |
| 5 | 16 | F | IVC, R iliac, fem, pop |
No | 3 | 0 | OCP EBV infection |
FVL het FVIII |
None | None |
| 6 | 15 | M | R iliac, fem |
No | 30 | 0 | Obesity | FVL het FVIII |
None | APS Trisomy 21 |
| 7 | 17 | M | R SC | No | 9 | 1 | Chronic effort (baseball pitcher) |
n/a | Paget- Schroetter |
None |
| 8 | 11 | M | R iliac, L iliac, IVC |
Yes | 7 | 4 | Trauma | FVIII, AT (mild, acquired), FVL het, LA, Lp(a) |
May- Thurner |
APS with thrombotic storm |
| 9 | 15 | M | L iliac, Fem |
No | 1 | 2 | Trauma | LA, Beta-2- GP1, ACA |
None | APS |
| 10 | 17 | F | R fem, pop, IVC |
Yes | 5 | 2 | Obesity, OCP |
FVIII, FVL het, LA |
None | None |
| 11 | 19 | M | L fem, pop |
No | 6 | 8 | ALL L-asp |
AT (mild, acquired), PS (mild, acquired), FVIII |
None | None |
| 12 | 17 | F | L iliac, fem, pop |
Yes | 6 | 12 | OCP | FVL het, PC (mild, inherited), FVIII |
None | None |
| 13 | 11 | F | L fem | Yes | 6 | 8 | None | PS (sev, inherited) LA |
May- Thurner |
None |
| 14 | 16 | M | IVC, L iliac, B fem |
No | 4 | 6 | None | LA, FVL/ PT 20210 dual het |
None | None |
| 15 | 18 | F | L iliac, Fem, pop |
No | 1 | 1 | Immobility | FVIII, LA, FVL het, PS (mild, acquired) |
May- Thurner |
APS |
| 16 | 14 | M | L SC, ax | Yes | 4 | 48 | None | FVIII, LA, AT (mild, acquired), PC (mild, acquired) |
n/a (obstruct- ted by thrombus) |
None |
Abbreviations: DVT=deep venous thrombosis; PE=pulmonary embolism; dx= diagnosis; rx=treatment; F=female; M=male; fem= femoral; pop=popliteal; IVC=inferior vena cava; SC=subclavian; BC=brachiocephalic; ax=axillary; SVC=superior vena cava; L= left; R=right; B=bilateral; OCP=oral contraceptive pill (containing estrogen); FVIII=elevated factor VIII activity; LA=lupus anticoagulant; PS=protein S deficiency; sev=severe; FVL het=heterozygous factor V Leiden polymorphism; n/a=not available or not applicable; EBV=Epstein-Barr virus; ALL-acute lymphoblastic leukemia; L-asp: L-asparaginase; APS=antiphospholipid antibody syndrome