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Overview on therapeutic mechanisms of HBO2 related to elevations of tissue oxygen tensions. The figure outlines initial effects (denoted by boxes) that occur due to increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and their consequences. Other abbreviations: GF=growth factor, VEGF=vascular endothelial growth factor, HIF= hypoxia inducible factor, SPCs=stem/progenitor cells, HO-1 =heme oxygenase-1, HSPs=heat shock proteins.
