Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Epilepsia. 2011 Jan;52(Suppl 1):39–46. doi: 10.1111/j.1528-1167.2010.02909.x

Figure 2.

Figure 2

Non-convulsive hippocampal seizures and network remodeling in transgenic mouse model of AD. Left: spontaneous seizure with first appearance of epileptiform discharges (arrows) in hippocampal depth electrodes and subsequent generalization in the hAPP J20 mouse. No behavioral signs were evident during or after the seizure episode. Right: seizure-related plasticity absent in wild type hippocampus is clearly demonstrated in hippocampal circuitry of hAPP J20 mice, including mossy fiber sprouting (upper), ectopic NPY expression in mossy fibers (center), and loss of calbindin staining (lower) in dentate granule cells. Modified from Palop et al. (2007).