Skip to main content
. Author manuscript; available in PMC: 2011 Mar 16.
Published in final edited form as: Pediatr Infect Dis J. 1998 Nov;17(11):1007–1011. doi: 10.1097/00006454-199811000-00008

Table 1.

Dosing of antifungal agents in neonates and children.

Drug N
(infants)		 Suggested dose Birth weight (g) Gestational age (weeks) Comments Reference
Amphotericin B deoxycholate 13 1 mg/kg/day 1200 (800)* 27 (4.9)* N/A [10]
Lipid amphotericin B 28 5 mg/kg/day 1060 (480–4900)** 27 (24–41)** Infant weight highest predictor of clearance [21]
Fluconazole 55 12 mg/kg/day 1020 (451–7125)** 26 (23–40)** Loading dose may be required. [35]
Micafungin 43 10–12 mg/kg/day 1162 (530–4500)* 27 (23–40)* N/A [55–57]
Anidulafungin 0 1.5 mg/kg/day Not studied in young infants Not studied in young infants Dose evaluated in pediatric patients aged 2–17 years. Loading dose (double the maintenance dose) required. [60]
Voriconazole 0 4 mg/kg every 12h Not studied in young infants Not studied in young infants Dose evaluated in pediatric patients aged 2–17 years. Loading dose (double the maintenance dose) required. [47]
Caspofungin 0 50 mg/m2/day Insufficiently studied in young infants Insufficiently studied in young infants Dose evaluated in pediatric patients aged 2–17 years. Loading dose (double the maintenance dose) required. [52]
*

Mean (SD);

**

Median (range);

CSF: cerebrospinal fluid; N/A: not applicable.

1

Saez-Llorens X, Macias M, Maiya P, et al. Pharmacokinetics and safety of caspofungin in neonates and infants less than 3 months of age. Antimicrob Agents Chemother. 2009 Mar;53(3):869–75.