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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Hepatology. 2010 Dec;52(6):1897–1905. doi: 10.1002/hep.23921

Fig. 7. Effect of biliverdin reductase (BVR) knockdown on antiviral activity.

Fig. 7

(A) The efficiency of BVR knockdown was determined by WB after transfection of BVR siRNA or scrambled controlled RNA into NS (left panel) or FL (right panel) replicons. Real-time RT-PCR measurements for HCV RNA were performed after control vehicle or BV (20 µM) overnight incubation in both replicon lines (B left panel). Note that the antiviral activity of BV was significantly enhanced (P < 0.01) when BVR was knocked down. In B (right panel) HCV RNA was quantified after control vehicle or BR (100 µM) overnight incubation in both replicon lines. BVR knockdown had no effect on the antiviral activity of BR. Each graph is the mean +/− SEM of 5–6 determinations for each treatment. (## not significant), (* p < 0.01, ** p < 0.005).