Fig. 1.

Effects of 150 μM glibenclamide on twitch at 60% of fatigue. a In representative trace 1, the recorded tension at the start of the experiment. In trace 2, the recorded tension approximately 1 h after stimulating at a frequency of 0.2 Hz. In trace 3, 5 min in the presence of glibenclamide increased the tension in the fatigued muscle. Trace 4 shows the recorded tension 10 min after glibenclamide washout. b Graphs showing the effects of glibenclamide on single twitch tension. Glibenclamide produced a significant increase in both total and maximal tension of twitches in fatigued muscle fibers (n = 4). Asterisks indicate P < 0.05