Fig. 2.

Effects of glibenclamide on tetanic force. a Representative traces showing the effect of glibenclamide (150 μM) on tetanic tension of fatigued muscle fibers. The stimulation frequency used was 5 Hz. 1 Tetanic tension at the start of the experiment (control). 2 Tetanic tension after 10 min of stimulation, muscle fibers were fatigued at this point. 3 When glibenclamide was added to the bath the tetanic tension of the fatigued muscle increased. 4 Tetanic tension after 5 min of glibenclamide washout in which tetanic tension was further decreased is shown. b Graphs showing the effect of glibenclamide on peak tension and tension-time integral of fatigued muscle fibers. Asterisks indicate P < 0.05