Table 1.
Characteristics of subjects in the methylation analysis
| Characteristic | Individuals included in the methylation analysis (n=388) | Individuals included in the entire study (n = 1121) |
|---|---|---|
| Age, mean (SD), y | 57.8 (9.1) | 57.5 (9.6) |
| Male—no. (%). | 246 (63.4) | 712 (63.5) |
| Smoker—no. (%) | 58 (15.0) | 164 (14.5) |
| Alcohol drinker — no. (%) | 123 (33.0) | 340 (31.5) |
| Treatment | ||
| Placebo | 123 (31.7) | 372 (33.2) |
| Aspirin 80mg/d | 137 (35.3) | 377 (33.6) |
| Aspirin 325 mg/d | 128 (33.0) | 372 (33.2) |
| Treatment | ||
| Placebo | 190 (49.0) | 505 (49.5) |
| Folate 1 mg/d | 198 (51.0) | 516 (50.5) |
| Race or ethnic group--no. (%) | ||
| White | 325 (83.8) | 958 (85.5) |
| African American | 22 (5.7) | 68 (6.1) |
| Hispanic | 22 (5.7) | 61 (5.4) |
| Other | 19 (4.9) | 34 (3.0) |
| BMI, mean (SD) | 27.3 (4.6) | 27.4 (4.5) |
| Baseline plasma folate, mean ± (SD), (nmol/l) | 20.9 (15.4) | 23.3 (15.6) |
| Year three plasma folate, mean ± (SD), (nmol/l) | 53.4 (36.5) | 50.6 (34.7) |
| Baseline RBC folate, mean ± (SD), (ng/ml) | 396.4 (141.5) | 407.9 (152.9) |
| Year three RBC folate, mean ± (SD), (ng/ml) | 809.3 (345.5) | 836.8 (303.5) |
| Dietary intake | ||
| Total calories, mean ± (SD), (kcal/d) | 1601.4 (624.8) | 1634 (667.0) |
| Carbohydrates, mean ± (SD), g per day | 180.3 (72.4) | 185.9 (77.4) |
| Fat—total, mean ± (SD), g/d | 63.7 (32.6) | 65.1 (34.3) |
| Fiber, mean ± (SD), g/d | 12.8 (5.9) | 13.3 (6.0) |
| Folate, mean ± (SD), μg/d | 305.0 (7.7) | 319.9 (156.6) |
| Protein, mean ± (SD), g/d, g/d | 64.2 (25.2) | 65.4 (27.1) |