Table 3.
Hazard Ratios (HR) and 95% Confidence Intervals (CI) for Incident Cardiovascular Disease per copy of the FTO Risk Allele (A)
| All Women | |||
|---|---|---|---|
| No. of events | HR for CVD (95% CI) | P | |
| Crude model (n=21,674) | 664 | 1.11 (0.99–1.24) | 0.06 |
| Model 1* (n=19,004) | 560 | 1.14 (1.01–1.28) | 0.03 |
| Model 2† (n=19,004) | 560 | 1.10 (0.97–1.23) | 0.13 |
| Model 3‡ (n=18,826) | 555 | 1.09 (0.97–1.23) | 0.15 |
| Women Expending >8.8 MET hours/week | |||
| Crude model (n=10,841) | 263 | 1.01 (0.85–1.20) | 0.92 |
| Model 1* (n=9,486) | 223 | 0.98 (0.81–1.18) | 0.82 |
| Model 2† (n=9,486) | 223 | 0.96 (0.79–1.16) | 0.68 |
| Model 3‡ (n=9,486) | 222 | 0.96 (0.79–1.16) | 0.67 |
| Women Expending ≤ 8.8 MET hours/week | |||
| Crude model (n=10,833) | 401 | 1.18 (1.02–1.35) | 0.02 |
| Model 1* (n=9,518) | 337 | 1.26 (1.08–1.46) | 0.004 |
| Model 2† (n=9,518) | 337 | 1.19 (1.02–1.38) | 0.03 |
| Model 3‡ (n=9,431) | 333 | 1.19 (1.02–1.39) | 0.03 |
Crude model adjusted for age and randomized treatment assignment.
*
Model 1: crude model additionally adjusted for alcohol use, caloric intake, saturated fat and fiber intake, smoking, and parental history of myocardial infarction.
†
Model 2: Model 1, additionally adjusted for BMI and BMI2.
‡
Model 3: Model 2, additionally adjusted for cholesterol lowering medication, total cholesterol, LDL-C, HDL-C, TG, hsCRP, menopausal status, post-menopausal hormone therapy, hypertension, diabetes and the metabolic syndrome.