Table 4.
Risk of Cardiovascular Disease According to FTO Genotype Risk Categories and Physical Activity Level
| >8.8 MET-hours/week | 8.8 MET-hours/week | |||||
|---|---|---|---|---|---|---|
| Low-Risk | Medium-Risk | High-Risk | Low-Risk | Medium-Risk | High-Risk | |
| C/C | A/C | A/A | C/C | A/C | A/A | |
| N | 3,913 | 5,173 | 1,755 | 3,863 | 5,230 | 1,740 |
| Mean BMI, kg/m2 (±SD) | 24.84 (4.22) | 24.89 (4.17) | 25.57 (4.73) | 26.31 (5.03) | 26.90 (5.45) | 27.82 (5.86) |
| No. of Events | 104 | 107 | 52 | 131 | 186 | 84 |
| Crude Model | 1.0 | 0.78 (0.60–1.03) | 1.13 (0.81–1.57) | 1.34 (1.04–1.73) | 1.39 (1.09–1.76) | 1.91 (1.44–2.55) |
| P-value | 0.08 | 0.48 | 0.03 | 0.008 | <0.0001 | |
| Model 1* | 1.0 | 0.78 (0.58–1.05) | 1.06 (0.73–1.54) | 1.14 (0.86–1.52) | 1.22 (0.93–1.58) | 1.83 (1.34–2.50) |
| P-value | 0.10 | 0.75 | 0.37 | 0.15 | 0.0001 | |
| Model 2† | 1.0 | 0.79 (0.59–1.05) | 1.01 (0.70–1.46) | 1.06 (0.79–1.41) | 1.09 (0.84–1.42) | 1.54 (1.13–2.11) |
| P-value | - | 0.10 | 0.96 | 0.71 | 0.52 | 0.007 |
| Model 3‡ | 1.0 | 0.78 (0.59–1.05) | 1.02 (0.70–1.47) | 1.04 (0.77–1.38) | 1.04 (0.79–1.36) | 1.49 (1.09–2.05) |
| P-value | - | 0.10 | 0.94 | 0.82 | 0.77 | 0.01 |
Crude model adjusted for age and randomized treatment assignment.
*
Model 1: crude model additionally adjusted for alcohol use, caloric intake, saturated fat and fiber intake, smoking, and parental history of myocardial infarction.
†
Model 2: Model 1, additionally adjusted for BMI and BMI2.
‡
Model 3: Model 2, additionally adjusted for cholesterol lowering medication, total cholesterol, LDL-C, HDL-C, TG, hsCRP, menopausal status, post-menopausal hormone therapy, hypertension, diabetes and the metabolic syndrome.