Table 1.
Antimicrobial and antiprotozoal activities of reported pyridinium quaternary compounds
| Entry | IC50/ EC50/ MIC/ MBC | Reference |
|---|---|---|
| 1 | MIC 9.8 (S. aureus), 39.1 (E. coli), 19.5 (C. albicans), and 9.8 (E. faecalis) µg/mL | (4) |
| 2 | MIC 1.4 (S. aureus), 11 (C. albicans), 6 (B. subtilis) and 22 (E. coli) µM | (5) |
| 3 | MBC 15.6 (S. aureus), 10.4 (E. coli), 16.3 (E. faecalis) µM | (6) |
| 4 – 5 | MBC 62.5 µg/mL (S. aureus, S. albus and MRS) | (7) |
| 6 | MIC 7 (S. aureus), 27 (E. coli), 13.5 (C. albicans) and 14 (B. subtilis) µM | (8) |
| 7 | IC50 1.5 µM (P. falciparum) | (9) |
| 8 | EC50 52 nM (FCR-3 - Chloroquine sensitive strain of P. falciparum) | (10) |
| 9 | MIC 1.1 (S. aureus), 1.4 (MRS), 1.4 (B. subtilis), 5.2 (E. coli) and 13.2 (P. aeruginosa) µM | (11) |
| 10 | IC50 0.5 nM (P. falciparum) | (12) |
| 11 | EC50 8 nM (P. falciparum) | (13) |
| 12 | IC50 0.65 nM (P. falciparum) | (14) |
| 13 | IC50 19 nM (P. falciparum) | (15, 30) |
| 14 | IC50 5.5 nM (P. falciparum) | (16, 30) |
| 15 | IC50 0.82 µM (L. donovani) | (17) |
S. aureus: Staphylococcus aureus; E. coli: Escherichia coli; C. albicans: Candida albicans; E. faecalis: Enterococcus faecalis; M. catarrhalis: Moraxella catarrhalis; B. subtilis: Bacillus subtilis; P. aeruginosa: Pseudomonas aeruginosa; P. falciparum: Plasmodium falciparum; L. donovani: Leishmania donovani; MRS: Methicillin resistant Staphylococcus