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. 2011 Mar 14;208(3):421–428. doi: 10.1084/jem.20110132

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© 2011 Ehninger and Trumpp

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Location of HSC niches in trabecular bone cavities. HSCs are located at the endosteum, which is lined by OBs and is remodeled by osteoclasts. OBs promote HSC maintenance. Vascular sinusoids are found close to the endosteum, but more frequently at greater distances. HSCs are also situated nearby sinusoids toward the center of the marrow. Perivascular nestin⁺ MSCs and the more abundant CAR cells promote HSC maintenance.