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. 2011 Mar 14;208(3):505–518. doi: 10.1084/jem.20101824

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© 2011 Sumaria et al.

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Figure 3. — Dermal γδ T cells are predominantly radioresistant and proliferate locally in the skin. (A) Degree of chimerism of γδ T cells (left) and αβ T cells (right) in various organs obtained 12 wk after reconstituting lethally irradiated WT mice with CD45.1 congenic bone marrow. Filled bars, host CD45.2; open bars, donor CD45.1. (B, left) Flow cytometry profiles of BrdU incorporation by epidermal and dermal T cells isolated from WT mice (n ≥ 5/group) 6 d after initial BrdU administration. (right) Frequency of cutaneous BrdU⁺ T cells 6 d after initial BrdU administration in WT mice (n = 5). (C, left) Degree of chimerism of cutaneous T cells obtained 19 mo after reconstitution (n = 8; chimeras generated as described in A). Right, percentage of host- or donor-derived epidermal and dermal T cells that are BrdU⁺ in chimeric mice 6 d after initial BrdU administration (n = 8). Data are representative of two to four independent experiments.