Table 1.
Summary of findings in WSP-1 and WSR-1 mice.
| Phenotype | Outcome |
|---|---|
| Sucrose fading (acquisition) | |
|
| |
| Appetitive measures | |
| Active lever responses | WSR-1 ≥ WSP-1 |
| Inactive lever responses | WSR-1 > WSP-1 |
|
| |
| Consummatory measures | |
|
| |
| 10S volume (ml) | WSR-1 = WSP-1 |
| Sucrose/ethanol volume (ml) | WSR-1 < WSP-1 |
| 10E volume (ml) | WSR-1 = WSP-1 |
| Sucrose/ethanol intake (g/kg ethanol) | WSR-1 < WSP-1 |
| 10E intake (g/kg ethanol) | WSR-1 = WSP-1 |
|
| |
| Reinforcement schedule | |
|
| |
| FR4: 10E intake (g/kg) | WSR-1 = WSP-1 |
| RR8: 10E intake (g/kg) | WSR-1 > WSP-1 |
|
| |
| Extinction time course | |
|
| |
| Rate | WSR-1 = WSP-1 |
| Active lever responses | WSR-1 = WSP-1 |
| Inactive lever responses | WSR-1 > WSP-1 |
|
| |
| Reinstatement (active lever) | |
|
| |
| Baseline | WSR-1 > WSP-1 |
| Oral prime | No reinstatement |
| Light cue | WSP-1 only |
| Combined cues | WSR-1 = WSP-1 |
| Inactive lever responses | No effects |
|
| |
| Home cage preference drinking | |
|
| |
| 5S intake (g/kg sucrose) | WSR-1 > WSP-1 |
| 5S/10E intake (g/kg ethanol) | WSR-1 = WSP-1 |
| Alcohol deprivation effect (5S/10E intake; g/kg ethanol) | No ADE; WSR-1 < WSP-1 for intake during first 2 days postdeprivation |