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. 2011 Apr;25(4):1333–1344. doi: 10.1096/fj.10-173625

Figure 2.

Figure 2.

HCN channel transcripts are unaltered in 6- to 10-wk-old MitoPark mice. Left panel: in situ hybridization of mRNA encoding HCN1–4 and TH in coronal sections were performed in control (c) and MitoPark (M) mice at 6, 10, and 21 wk of age. Note the decrease in TH mRNA at the level of the SNc/VTA at the 21 wk time point, although HCN levels were unaltered at any time point. Right panel: quantification of mRNA levels at 10 wk of age (n=4 pairs of control and MitoPark mice). TH, HCN2, and HCN3 mRNA levels were not significantly affected at this time point.