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. 2011 Apr;25(4):1198–1207. doi: 10.1096/fj.10-167924

Figure 2.

Figure 2.

EGCG inhibits hotspot AR mutant T877A-mediated transactivation. A) CV1 cells were transfected with pSG5-T877A mutant of AR (2 μg), MMTV-luc reporter (1 μg), and Renilla luc (50 ng). Graphs represent fold of hormone induction compared with value for the non-hormone-treated group, which was set as 1. *aP < 0.01 vs. control group; *bP < 0.01, **bP < 0.05 vs. R1881 group; 1-way ANOVA followed by Tukey's HSD test. B) LNCaP cells were transfected with MMTV-Luc reporter and were treated 24 h post-transfection with or without 1 nM R1881 and with indicated concenctration of EGCG. Graphs represent fold of hormone induction compared with value for the non-hormone-treated group, which was set as 1. *aP < 0.01 vs. R1881 control group; 1-way ANOVA followed by Tukey's HSD test. C) LNCaP cells were transfected with PSA promoter containing reporter and were treated 24 h post-transfection with or without 1 nM R1881 and with indicated concentration of EGCG and casodex. *aP < 0.01 vs. control group; *bP < 0.01vs. R1881 group; 1-way ANOVA followed by Tukey's HSD test.