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Model depicting the effect of EGCG on AR-mediated signaling. EGCG could compete with natural AR agonist DHT to physically interact with the expressed AR protein. Once bound, it decreased the interdomain interaction of AR, leading to a decrease in AR protein expression and, hence, a decrease in AR transactivation functions. This resulted in decreased expression of AR target genes and thus might negatively influence the growth of PCa cells in vitro and in vivo.
