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. 2011 Apr;25(4):1254–1263. doi: 10.1096/fj.10-175208

Figure 4.

Figure 4.

The FPR2 receptor is responsible for stimulation of neutrophils by SLUSH peptides. A) Neutrophil stimulation with or without the FPR1- or FPR2-specific inhibitors CHIPS or WRW4, respectively. fMLP and MMK1 are synthetic control ligands of FPR1 and FPR2, respectively. Data represent means ± se of ≥3 independent experiments. *P < 0.05; ***P < 0.001 vs. no inhibition. B) Stimulation of FPR1, FPR2, and FPR3-transfected HL60 cells by SLUSH peptides. Untransfected HL60 cells exhibited no response (mean fluorescence values <1, data not shown). Open circles denote FPR2-transfected HL60 cells; solid circles denote FPR1-transfected HL60 cells; triangles denote FPR3-transfected HL60 cells. Data represent means ± se of ≥3 independent experiments.