. Author manuscript; available in PMC: 2011 Dec 15.

Published in final edited form as: Clin Cancer Res. 2010 Dec 15;16(24):6169–6176. doi: 10.1158/1078-0432.CCR-10-0281

Table 3.

Estimated odds ratios and 95% confidence intervals of grade 4 hematological toxicity associated with CYP2B6, CYP3A4, and GSTA1 genotypes in SWOG 8897

Genotype	# with grade 4 vs without grade 4 toxicity	Adjusted OR (95% CI)^†	Adjusted P-value^†
CYP2B6 (rs3745274)
GG	115/135	1.00
TT/GT	94/105	1.05 (0.72–1.53)	0.81
CYP3A4 (rs2740574)
AA	186/213	1.00
GG/AG	27/30	1.03 (0.59–1.82)	0.91
GSTA1 (rs3957356)
GG	71/93	1.00
GA/AA	121/129	1.29 (0.86–1.94)	0.21

^†

Footnote: Factors adjusted in the multivariate models include age, menopausal status, chemotherapy (CAF vs. CMF), tamoxifen treatment, and time from surgery to randomization.