Table 1.

Markers with strongest association between sarcoidosis and genetic ancestry based on a genome-wide ADMIXMAP analysis of unrelated sarcoidosis 1,026 cases and 316 controls

		Affected-only			Ancestry Association
GENOMIC POSITION	Marker	aRR	95%CI	P value	aOR	95%CI	P value
2p13.3-2q12.1	Rs1444543	0.67	0.52-0.88	0.004	0.69	0.54-0.89	0.003
2q35-2q36.3	Rs4674659	0.69	0.53-0.91	0.008	0.72	0.55-0.93	0.01
4q31.21-4q34.1	Rs1530044	1.53	1.14-2.05	0.005	1.27	0.94-1.71	0.1*
5p13.3-5p13.2	Rs35397	1.46	1.13-1.90	0.005	1.52	1.16-1.99	0.003
5q23.1-5q31.2	Rs30533	0.67	0.51-0.89	0.005	0.72	0.56-0.94	0.01
6p24.3-6p12.1	Rs11966463	1.90	1.36-2.64	0.0002	1.49	1.07-2.08	0.02
6q23.3-6q25.2	Rs276497	0.67	0.52-0.87	0.003	0.68	0.53-0.88	0.003
8p21.3-8p11.21	Rs1462906	0.65	0.5-0.85	0.002	0.73	0.57-0.94	0.02
17p13.3-17p13.1	Rs8070464	1.68	1.26-2.25	0.0005	1.37	1.01-1.85	0.04

Note: Regions were selected satisfied all of the following criteria: (1) at least one SNP with an Affected-only p-value < 0.01 (i.e. absolute Z-score > 2.576); (2) more than 3 SNPs with Affected-only p-values < 0.05; and (3) at least one SNP with an Ancestry Association p-value < 0.05.

(aRR = ancestry risk ratio; aOR = ancestry odds ratio)

^*adjacent SNP had p value <0.05